Studies on the relationship between intestinal factor and pulmonary lesion during shock
- VernacularTitle:休克过程中小肠因素与肺损伤的关系研究
- Author:
Fayu CHEN
- Publication Type:Journal Article
- Keywords:
Shock;
Intestine, small;
Pulmonary edema
- From:
Chinese Journal of Pathophysiology
1989;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of intestinal factor on pulmonary lesion during shock were investigated. Anesthetized rabbits were dividcd at random into SMAO shock group(n=11) and sham shock group (n=8). Occlusion of SMA for 60 min followed by reperfusion produced a significant elevation of pulmonary capillary permeability index (PCPI), an increase of MDA in lung tissue, ultrastructural damage of type Ⅱ pneumocytes, and hyperemia, edema and haemorrhage in alveoli or bronchioli. There was a positive correlation between intestinal mucosal lesion and pulmonary lesion. However, PaO_2 showed no significant declination in this shock model. In vitro, the plasma collected from SMV blood of cats, which had been subjected to SMAO for 90 min, exerted a deleterious effect on isolated perfused rat lungs, characterized by elevation of pulmonary arterial perfusion presure and PCPI, increase in LDH and MDA in the perfusate. These results suggest that the humoral factors released from ischemic intestine into circulation may be, at least partially, accounted for the pulmonary damage during shock.
