The effect of normobaric hypoxia on the density of ? and ?_1 adrenoceptors in the rat lung
- VernacularTitle:常压缺氧对大鼠肺组织?和?_1肾上腺能受体数目的影响
- Author:
Jianming XIE
- Publication Type:Journal Article
- Keywords:
Anoxia;
Receptors, adrenergic;
Hypertension, pulmonary
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
The rats were kept in normobaric hypoxic chamber(O_2=10%) for 24 hours or 1,2,4 weeks(6 hrs./day, 6day/wk.). The adrenoeeptors of lungs were measured by binding study. The result showed that The beta adrenoceptors decreased by 24 hours of hypoxia and unexpectedly increased at 1 week of hypoxia. The exposure to hypoxia for 2 and 4 weeks led to a decrease in beta adrenoceptors again. By contrast, the alpha adrenoceptors increased markedly at 24 hours and 4 weeks of hypoxiao A higher, but not significant density of alpha_1 adrenoceptors was also found at 1 and 2 weeks of hypoxia. The affinity of beta and alpha_1 adrenoceptors did not change after hypoxia. The data indicated that the changes in adrenoceptors induced by hypoxia may play a role in the development of hypoxic pulmonary hypertension.
