A comparison of the protective action of verapamil and anisodamine on anoxia-reoxygenation injury of isolated perfused rat heart
- VernacularTitle:山莨菪碱和异搏定对离体大鼠心脏“缺氧—复氧”损伤的防治作用比较
- Author:
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Calcium channel blockers;
Heart;
Perfusion
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
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Abstract:
This work compared the preventive and therapeutic effect of verapamil and anisodamine on anoxia-reoxygenation injury (oxygen paradox) of isolated rat heart performed with Langendorff apparatus. Results showed that addition of anisodamine (1.64?10~(-4)M) or verapamil (5?10~(-8)M) to the perfusion fluid during anoxic period significantly ameliorated the anoxia-reoxygenation injury of the heart; e. g., the recovery of cardiac functions, the improvement of myocardial acidosis, the decrease in leakage of LDH from myocardium, and in the accumulation of lipid peroxides and calcium. When the drugs were given during the period of reoxygenation, anisodamine was very effective too, but verapamil had no effect. From these results it may be suggested that anisodamine has more extended anti-oxygen-paradox effect in ddition to calcium channel blocker action.
