Inhibitory effect of intracerebroventricular taurine on fever in rabbits caused by db-cAMP
- VernacularTitle:侧脑室灌注牛磺酸对家兔db-cAMP性发热的影响
- Author:
Yuejin CHEN
- Publication Type:Journal Article
- Keywords:
Fever;
Taurine;
Adenosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
1989;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Thirty albino New Zealand rabbits were divided into three groups at random, ten in each group, which were N~6-2'-O-dibutyryladenosine-3', 5'-cyclic monophosphate (db-cAMP) + taurine (Tau), normal saline (NS) + Tau and db-cAMP+ NS. Tau, dbcAMP and NS were injected into the rabbit's ventricles by intracerebroventricular (ICV) rotate. The results showed that ICV Tau could inhibite the fever induced by ICV dbcAMP in the single long phase hyperthermic duration. The mean thermal response indiexs of the groups within six hours (TRI6) were 7.10?2.447 0.21?1.58 and 12.47?4.60 (P
