The effects of intravenous administration of naloxone on the biphasic fever induced by endotoxin and on the normal body temperature in rabbits
- VernacularTitle:静脉内注射纳洛酮对家兔内毒素性双相热和正常体温的影响
- Author:
Daxiang LU
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Endorphins;
Naloxone
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
With 28 of new zealand rabbits, following observations were carried out: effects of intravnnous admiaistration of naloxone, an antagonist of opiate receptor, (1) on the biphasie fever induced by endotoxin; (2) on the body temperature of the normal rabbits. The results obtained indicated: the biphasic fever, which was induced by endotoxin at a dose of 5?g/kg was not changed significantly by the pretreatment of naloxone. However, the body temperature of normal rabbit was decreased to-0.46℃ following the administration of naloxone. The authors suggest that the endogenous opioid peptides are not necessary in the pathogenesis of the endotoxin biphasic fever. However, they play probably some role in the maintaining of physiological body temperature of the rabbit.
