The changes of cardiac function during the shortly ischemic-reperfusion and the effect of superoxide dismutase
- VernacularTitle:家兔心脏短期缺血后再灌流时心功能的变化及SOD的影响
- Author:
Longjun DAI
- Publication Type:Journal Article
- Keywords:
Perfusion;
Free radicals;
Superoxide dismutase;
Coronary vessels
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
This study was performed to assess the effect of myocardial ischemicreperfusion on cardiac function and research the action of free radicals in the reperfusion injury by observing the effect of free radical scavenger (superoxide dismutase, SOD) in the shortly ischemic-reperfused rabbits. Three groups were studied: Group Ⅰ (SOD 300u/kg, n= 10) and Group Ⅱ (control, n= 8) were subjected to 15 rain of total occlusion of the left ventricular branch of coronary artery (LVB) followed by 10 min of reperfusion; in Group Ⅲ (n= 8), rabbits underwent continuous occlusion of LVB for 25 min. Cardiac index (CI), left ventricutar systolic peak pressure (LVSP), maximum rate of left ventricular pressure development (+dp/dr max), and maximum rate of fall of left ventricular pressure (-dp/dr max) in the Group Ⅱ were significantly lower than those in the Group Ⅰ and Group Ⅲ during reperfusion. According to the Sunamori's method with which the myocardial ultrastructure can be analysed quantitatively, the most serious injury in the ischemic area was found in Group Ⅲ, then Group Ⅱ and Group Ⅰ; in the non-ischemic area, obvious injury was only found in Group Ⅱ. The results suggested that the cardiac function was obviously suppressed during reperfusion after short period of regional ischemia and that the oxygen free radicals might play an important role in this reperfusion injury. The features of myocardial ultrastructure indicated that ultrastructural damage implicated not only ischemic area but also non-ischemic area during reperfusion. was obviously suppressed during reperfusion after short period of regional ischemia and that the oxygen free radicals might play an important role in this reperfusion injury. The features of myocardial ultrastructure indicated that ultrastructural damage implicated not only ischemic area but also non-ischemic area during reperfusion.
