The effect of Salviae miltiorrhizae on cardiac pump function of rabbits during hemorrhagic shock
- VernacularTitle:复方丹参注射液对失血性休克家兔心泵功能的影响
- Author:
Zhichao WANG
- Publication Type:Journal Article
- Keywords:
Sheck, hemorrhagic;
Cardiac output
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
This paper reports the effect of salviae miltiorrhizae composition on cardiae pupm function of rabbits during hemorrhagic shock. Two groups of rabbits were narcotized with 1% procain and blood was drawn out from femonal artery and the artery blood pressure was kept at 40-50 mmHg for 90 minutes. (1) The treated group: The rabbits were kept in low blood pressure for 90 minutes and then, they were transfused into the femoral vein 5% glucose and normal saline 15ml/kg in which was added salviae miltiorrhizae composita 2ml/kg. At the same time, the drawn blood was transfused into vein. The time was kept for 30 minutes. ABP, CVP, HR, and CO were measured before shock, during shock, after transfusion O rain, 30 min, 60 min, and 120 min, and SV, CI, LVSW and TPR were taken respectively. (2) Con- trol group, Contained no salviae miltiorrhizae composita in the transfusion.The results demonstrated that the salviae milttorrhizo composita can increase ABP, SV, LVSW, and decrease TPR of animals during shock, but the effective time was short. The mechanism may be a redistribution of blood flow in body, dilate coronary artery, increase speed of blood flow in capillary of myocardium, enhance infusion in local myocardial and improve blood supply, so it can improve pump function of rabbit heart during hemorrhagic shock.
