Studies on mutagenicity of alternariol monomethyl ether in V_(79) chinese hamster cells
- VernacularTitle:交链孢醇单甲醚诱发V_(79)细胞突变的研究
- Author:
Meng ZANG
- Publication Type:Journal Article
- Keywords:
Alternaria;
Mutagenicity tests;
Esophageal neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Alternariol monomethyl ether(AME) was isolated, purified and crystallized from the extracts of the corn inoculated with Alternaria alternata which was separated from the contaminated rice in the high incidence area of esophageal cancer, Lixian County. AME is one of the major metabolic products of A. alternata. In this paper, the mutagenic potency of AME was detected with the V_(79) Chinese hamster cells. The experimental results showed that with or without rat liver microsomes (S-9), AME could induce 6-Thioguanine resistant (6-TG~r) mutation in V_(79) cells and their dose-effect curves were similar. The mutagenicity of AME without S-9 was stronger than that of AME with S-9. So it is considered that AME is a direct mutagen which doesn' t need to be activited metabolically by S-9. AME may play an important role in the etiology of esophageal cancer.
