Synergistic action of iodine-deficiency and fluorine-intoxication on the thyroid in rats
- VernacularTitle:缺碘和氟中毒对大鼠甲状腺的协同作用
- Author:
Zhizhong GUAN
- Publication Type:Journal Article
- Keywords:
fluorine;
iodine;
thyroid gland
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
212 Wistar rats were divided randomly into five groups, each of which was fed on one of the following regimes respectively: (1) normal iodine and fluorine, (Ⅱ) normal iodine, 10 ppm fluorine, (Ⅲ) normal iodine, 30 ppm fluorine, (Ⅳ) low iodine, normal fluorine, (Ⅴ) low iodine, 10 ppm fluorine. The total experimental period was seven months. The results showed that severe morphologic and functional damages of the thyroid appeared in the rats drinking water containing 30 ppm fluorine, but only slight abnormal ultrastructural changes of the thyroid cells appeared in the rats drinking water containing 10 ppm fluorine; the rats with iodine deficiency showed proliferative changes of the thyroid; the rats on iodine deficient diet and drinking water containing 10 ppm fluorine showed morphologic and functional damages as well as proliferation. The study suggests that there is a synergistic action of iodine deficiency and fluorine-intoxication on the thyroid.
