Anisodamine (654-2) decreases endotoxin binding to rat heart and hepatocytes
- VernacularTitle:山莨菪碱对内毒素与大鼠离体心脏及肝细胞结合的抑制作用
- Author:
Chaoshu TANG
- Publication Type:Journal Article
- Keywords:
Endotoxins;
Heart;
Liver
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
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Abstract:
Rat heart was perfused on Langendorff apparatus with Krebs-Henseteit buffer which contained Fluorescein Isothiocyanate-Lipopoly-saccharide (FITC-endotoxin, 25?g/ml) with or without 654-2 (25?g/ml), and the amount of endotoxin(ET) in the perfusion solution was measured before and after perfusion using fluorescence spectrometer. It was discovered that 654-2 decreased the binding of ET to myocardium by 47.7%. The difference between the 654-2 treated and the control group was significant (P
