Effect of hypobaric hypoxia and glucocorticoids on ?-adrenoceptor in rat cerebral cortex and lung
- VernacularTitle:低压性缺氧及糖度质激素类药物对大鼠大脑皮层和肺内?-受体的影响
- Author:
Xuenong BO
- Publication Type:Journal Article
- Keywords:
Anoxia;
Receptors, adrenergic, beta;
Glucocorticoids;
Cerebral cortex;
Lung
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
This study showed that when the rat lived in simulated altitude of 4000 m. the ?-receptor number in cerebral cortex increased first, then returned to normal gradually. The receptor number in rat lung reduced first. then rose high above the normal, and then dropped to normal. On the first day after the rats returned to normal atmosphere the ?-receptor number in both tissues increased moderately. No significant change of Kd values was observed in the experimental groups. The Hill numbers were around 1. The hydrocortisone, dexamethasone and betamethasone could increase ?-receptor number in both tissues of normal rats, and had the same effect on hypoxic rat cerebral cortex. The results mentioned above indicate that the three glucocorticoids can reverse the reduction of ?-receptor number in rat lung during the initial stage of hypoxla, which may lead part of the beneficial effect of glucocorticoids on high-altitude disease.
