Induction of mice spleen suppressor cell activity by Trypterygium Wilfordii Hook f
- VernacularTitle:雷公藤片诱导小鼠脾脏抑制细胞活性的研究
- Author:
Bo ZHAO
- Publication Type:Journal Article
- Keywords:
Medicine, chinese traditional;
Suppressor cells
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
We have studied the induction of mice spleen suppressor cell activity by Trypterygium Wilfordii Hook f. both in vivo and in vitro. We detected the suppressor cell activity in mice which were administrated with the drug for different days & found that after giving the drug for 5 or 9 days, the suppressor cell activity elevated remarkly, but for 12 & 15 days, the suppressor cell activity varied indefinitely, some were higher & some were lower. The drug inhibited the response of spleen cell to Con A too. But the release of inhibition on Con A responsibility was earlier than the recovery of elevated suppressor cell activity. Cocultured with the drug, slight promotion on cell proliferation was observed. The normal spleen cells cocultured with the drug for two days suppressed the normal spleen cell proliferation stimulated by Con A, the suppressive rate was comparable to that of Con A induced suppressor celll.
