Studies in staphylococcal fever and its hyperthermic ceiling
- VernacularTitle:家兔葡萄球菌性发热及其热限的探讨
- Author:
Yipeng WANG
- Publication Type:Journal Article
- Keywords:
Fever;
Staphylococcus;
Pyrogens;
Adenosine cyclic monophosphate
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Staphylococcus albus (St albus) given intravenously to conscious rabbits produced a dose-dependent fever. When the St albus doses reached a certain limit, hyperthermic ceiling was approached. The pyrogenicity of plasma increased progressively along with the increase of St albus doses. When hyperthermic ceiling was approached, pyrogenicity of plasma stopped raising any further. Fever induced by St albus was associated with a dose related increase in the concentration of cAMP in csf as well as that in the plasma. The increase of cAMP in plasma and in csf was limited at the occurrence of upper limit of fever. It is concluded that cAMP may be an important central mediator in the fever induced by staphylococci, whilst the limitation of production and release of EP and the limitation of increase of cAMP in central nervous system may be two important factors in "staphylococcus hyperthermic ceiling".