Approach to relationship between the implantation site of mouse uterine cervix carcinoma No 14 and its metastasis
- VernacularTitle:小鼠子宫颈癌14号移植部位与转移关系的初步探讨
- Author:
Jin GAO
- Publication Type:Journal Article
- Keywords:
Cervix neoplasms;
Transplantation;
Neoplasm, metastasis;
Lung;
Liver
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Results of observation on the relationship between the different implantation site and metastasis of cancer cells were reported. In the group of intramuscular implantation, lymphatic metastasis was 100%, lung metastasis also was 100% and metastasis in the kidney exhibited 26%. In the group of footpad inoculation, the lung metastasis was 84%, lymphatic metastasis presented 100%, kidney metastasis only exhibited 7%. in the group of intravenous inoculation, lung metastasis was 88%, itsr forms of metastasis most exhibited large nodules; lymphatic metastasis presented 74%; the large metastatic tumors were found in the gluteal part, dosal part, abdominal wall and some parts of four limbs. The survival time of tumor bearing mice of above three groups was more than 20 days. In the group of postocular venous plexus inoculation, lung metastasis was 60%, lymphatic metastasis was 65% In the group of intraspleenic inoculation, lung and liver metastases were 44% respectively. No metastasis was observed in lymph nodes. The survival time of tumor-bearing mice of latter two groups was in 7—14 days. Our results demonstrate the influence of the site of transplanted tumor on the formation of metastasis. The relationship between the site of transplanted and metastasis as well as metastatic mechanism are discussed.
