“TWO-ROUTE CHEMOTHERAPY”USING AHIGH-DOSE OF HD-CISPLATINE IN ARTERIAL INFUSION
- VernacularTitle:大剂量顺铂动脉灌注“双路”化疗
- Author:
Mingjing CHEN
- Publication Type:Journal Article
- Keywords:
"Two-Route" chemotherapy;
High-Dose;
Cis- Diammindichlorplotiau(?) (HD-DDF) Sodium thiosulfate (STS) Using HD-DDP in arterial infusion Using STS in venous infusion
- From:
Journal of Kunming Medical University
1988;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Eight patients with malignant tumors, testified by pathological examination. were treated by " Two-Route Chemotherapy" using a high dose of HD-Cisp latine in arterial infusion (AI). Among them 5 cases were primary or metastatic liver carcinoma, 3 cases were Ⅲ-Ⅳ stage breast carcinoma.One or two courses were given in each patient. The dosage of DDP in the first course was 80 - 100mg/m~2. the second was 120-150mg/m~2 with STS Ⅳ as a protective agent. The total lasted 14 courses.When DDF was given alone in AI, the serum creatine level increased temporarily, but there was no significant increase when both DDP and sodi um thiosulfate were given.Results: Among 5 cases of liver carcinomas I was complete response 3 were partial response and 1 was stable. Among 3 cases of Ⅲ-Ⅳ stage of breast carcinomas, all were partial response, giving a response rate of 8 (?) (7/8).
