Study on mutation in V_(79) cells and transformation in NIH/3T3 cells induced by the extract 261-B_2-3 of Alternaria alternata
- VernacularTitle:互隔交链孢霉提取物诱发V_(79)细胞突变和NIH/3T3细胞转化作用的研究
- Author:
Zigang DONG
- Publication Type:Journal Article
- Keywords:
Alternaria;
Mutagens;
Carcinogens;
Esophageal neoplasms
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The extract 261-B_2-3 of Alternaria alternata isolated from the corn in Linxian county which is an area with high incidence of esophageal cancer induced 6-thioguanine-resistant mutants in V_(79) cells and transformation in NIH/3T3 cells. There is mutation activity in presence or absence of rat-liver-microsome prepar-ations. Treated with a range of eoncentration(32ug/ml, 64ug/ml, 128ug/ml) of the extract, high rate of transformation different from the rate treated by solvent control, is found.The results show that this extract contains direct mutagen. The high infestationincidence of Alternaria alternata in the corn of Linxian county might play an important role in the causation ofesophageal cancer in this area.
