Preliminary autoradiographic research for disseminated intravascular coagulation
- VernacularTitle:弥散性血管内凝血的放射自显影研究
- Author:
Qubing SUN
- Publication Type:Journal Article
- Keywords:
Disseminated intravascular coagulation;
Autoradiography;
Reticuloendothelial system
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Disseminated intravascular coagulation was induced by injection of thrombin and EACA in rats.In the experimental group the rats, after injection of ~(125)I fibrinogen, received thrombin to produce DIC. The control group received saline instead of thrombin. The autoradiographic result indicated that the radioactive microthrombi were mainly situated in the glomeruli of kidney and pulmonary capillaries. By the use of HE and PTAH stain, however, the microthrombi could be found only in the glomeruli of the kidney but not in pulmonary capillaries. This indicated that autoradiography was more sensitive than histochemical and HE methods for detection of thrombi in microcirculation. It was also discovered that the reticuloendothelial cells of liver and spleen phagocytized a large amount of the radioactive materials. The materials might be radioactive fibrin or its monomer because ~(125)I fibrinogen has been attached to thrombin. In addition to these, the epithelium of convoluded tubules of kidney also absorb radioactive materials which might be peptides A and B.
