Cardiac output and local blood flow in acute hypoxic rat
- VernacularTitle:急性缺氧大鼠的心输出量和局部血流量
- Author:
Decheng LUO
- Publication Type:Journal Article
- Keywords:
Anoxia;
Cardiac output, Regional blood flow
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
Measurement of the cardiac output and local blood flow was accomplished in acute hypoxic rat with ~(99m)Tc-labeled toad red blood cells (~(99m)Tc-RBC) as biologic microspheres and the reference sample method (RSM). Hypoxia was produced by switching from room air to an 10% O_2-90%N_2 gas mixture. 40000-60000 of ~(99m)Tc-RBC were injected into the left ventricle of anaesthetized, artificially aerated rat and the reference sample was withdrawn from femoral arterial cannula in order to measure the cardiac output and local blood flow after 20 minutes inhaling hypoxic gas mixture. Results indicate that under a condition of artificial ventilation, acute hypoxia results in decrease of cardiac output and heart rate, and redistribute blood flow away from splanchmic organs to the heart and brain.
