Comparisons between acute pulmonary edema induced by kainic acid microinfusion and by electrolytic lesion to the lateral preoptic area of the hypotalamus in rats To research for mechanism of neurogenic pulmonary edema
- VernacularTitle:电解毁损与红藻氨酸微量注入大鼠下丘脑外侧视前区诱发急性肺水肿的比较——对神经源性肺水肿发病机理的探讨
- Author:
Dingfang YAO
- Publication Type:Journal Article
- Keywords:
Kainic acid;
Hypothalamic area, lateral;
Pulmonary edema
- From:
Chinese Journal of Pathophysiology
1986;0(04):-
- CountryChina
- Language:Chinese
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Abstract:
The pulmonary edema produced by electrolytic lesions of the lateral pre optic area (POA) of the hypotalamus can be reproduced by kainic acid (KA) microinfused in the POA of rats. KA group and electrolytic group showed similar patterns of lung pathology on gross and microscopic examination. The arterial blood pressdre and the frequency of discharge from the greater splanchnic nerve in KA group was increased more severely than in electrolytic group.The data indicate that there is a special and close ralation between lesion of POA and development of pulmonary edema. They also suggest that the changes in hemodynamics may not be a major factor in mechanisms of neurog enic pulmonary edema.
