Studies on the repair of oleic acid induced acute lung injury and the changes of elastase and ?-glucuronidase activities during injury
- VernacularTitle:油酸性肺损伤修复过程中某些酶活性的变化
- Author:
Xiangyin CHEN
- Publication Type:Journal Article
- Keywords:
Pulmonary alveoli;
Bronchi;
Lysosomes
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Acute lung injury was produced by injection of oleic acid (0.1 ml/kg) intravenously. Within 1 dey after oleic acid, the protein content, total cell counts, elastase, ?_1-antitrypsin and ?-glucuronidase activities were increased in BALF significantly. Histologic examination showed pulmonary hemorrhage, edema and interstitial infiltration of leukocytcs. 3 days after oleic acid, all above changes diminished. 7 days after injection of oleic acid, the changes both in BALF and histologic feature reached normal. The results suggest that, acute lung injury induced by oleic acid could recover completely in 1 week. The role of elastase and ?_1 -Antitrypsin in lung injury and repair was discussed. The possibility of oleic acid induced injury in other organs was noted as well.
