Effect of anisodamine on magnesium content of liver mitochondria during hemorrhagic shock
- VernacularTitle:山莨菪碱对失血性休克肝线粒体内镁含量的影响
- Author:
Qi ZHAO
- Publication Type:Journal Article
- Keywords:
Shock, hemorrhagic;
Magnesium;
Mitochondria
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
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Abstract:
In order to explore the cellular mechanism of antishock effect of anisodamine (654-2), the changes of intramitochondrial magnesium during late hemorrhagic shock were observed. Results showed that there exists a negative correlation between the blood plasma magnesium concentration and arterial blood pressure in shocked animals and at the same time the magneium content of liver mitochondria reduced significantly; 654-2 prevented the decrease of mitochondria magnesium and the increase of blood plasma magnesium, and improved the prognosis of the shocked animals. These results indicate that 654-2 may protect the liver mitochondria of shocked animals at a cellular and subcellular levels.
