The protection effect of sodium tanshinone Ⅱ A sulfonate against myocardiol calcium paradox
- VernacularTitle:丹参酮Ⅱ_A磺酸钠对心肌钙反常的保护作用
- Author:
Ping YUE
- Publication Type:Journal Article
- Keywords:
Myocardium;
Calcium channel blockers
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The myocardial calcium paradox model was made on isolated perfused guinea-pig heart. Sodium tanshinonc Ⅱ_A sulfonate (DS-201) was used as a protection agent. The protein release and the calcium uptake of the myocardium were measured to observe and evaluate the protection effect of DS-201 against myocardial calcium paradox. The effect was compared with that of verapamil, a known calcium antagonist, to study the calcium antagonism of DS-201. The results demonstrated that DS-201 acted as a calcium antagonist and contributed an outstanding protection to myocarcial calcium para- dox. DS-201 inhibited the calcium uptake and the protien (enzymes) release of the myocardium occured during the calcium paradox (P
