A study on effects of sodium selenite, hyaluronidase and anisodamine on infarction size and left ventricular myocardial contractility and relaxation in rat with myocardial infarction
- VernacularTitle:亚硒酸钠、透明质酸酶及山莨菪碱对大鼠心肌梗塞急性期左心室功能影响的比较研究
- Author:
Xiaolin TAN
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Hemodynamics;
Selenium;
Rats
- From:
Chinese Journal of Pathophysiology
1986;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The present study compared effects of sodium selenite(Se), hyaluronidase (Hy) and anisodamine(An) on infarction size(IS), left ventricular myocardial contractility (LVMC) and relaxation(LVMR) on the third day after the ligation of left coronary artery in rats. The results showed that Se, with the dose of 30?g/kg/day either before or after the ligation, has a same effect on reducing IS as Hy and An. However, Se, at the same time, can significantly improve LVMC and LVMR, which were evalued by indexes of LVSP, ?dp/dtmax and T value, while Hy and An can not. It is suggested that Se is superior to Hy and An when they are used in treatment of acute myocardial infarction.
