Electromicroscopic observation on the prevention and treatment of experimental pulmonary edema in rat treated with anisodamine
- VernacularTitle:山莨菪硷(654-2)预防大鼠实验性肺水肿的电镜观察
- Author:
Shuyun SU
- Publication Type:Journal Article
- Keywords:
Pulmonary edema;
Microscopy, electron
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
A preliminary study was conducted on prevention and treatment of adrenaline induced pulmonary edema in rat with anisodamine. An animal model of rat fatal pulmonary edema close to clinical neurogenic edema was made by intravenous injection of adrenaline. It is a kind of mixed pulmonary edema with both an increase in pulmonary capillary pressure and in permeability of pulmoary microvasculature. Anisodamine showed a pretty good preventive and therapeutic effect.The observation under eletron microscope:(1) In the group of edema: It showed that protein-rich fluid accumulated in the alveolar and interstitial space. The endothelial cells and epithelial cells were swollen and degenerated. Some of the basement membrance was lost and disintegrated.(2) In the group with anisodamine prevention and treatment: It revealed that all of the pathological changes diminished. The epithelium and endothelium were normal, edema disappeared. The interstitial space widen and alveolar septal thicken which was due to the repair of the inflammation resulting in proliferation of connective tissue. The results showed that anisodamine cart inhibit the pulmonary microvascular and alveolar permeability as well.
