The effect of gonadectomy on mortality and left ventricular function of experimental myocardial infarction in male and female rats
- VernacularTitle:摘除性腺对大鼠实验性心肌梗塞后死亡率和左室功能的影响
- Author:
Xing LU
- Publication Type:Journal Article
- Keywords:
Myocardial infarction;
Gonads;
Rats;
Sex factors
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of gonadectomy on mortality and left ventricular function following myocardial infarction (MI) were observed. Ligation of the left coronary artery or sham-operation was performed three weeks after gonadcctomy in male and female rats. The results showed that the mortality rate within 9 days after MI was lower in male gonadectomy group (GMI) than in control group (CMI), but there was no significant difference between female GMI and CMI. For the sham-operated rats, dp/dtmax, -dp/dtmax and LVSP, measured on the 9th day after operation, were much lower in male gonadectomy group (CS) than in male control group (CS), but these indeces showed no significant differences between male GMI and CMI, and also between male GMI and GS. The increase of the diameter of septal myocardial fiber in male GMI was more marked than in male CMI, but in female GMI it was less marked than in female CMI. It is suggested that the activity of gonads is involved in the compensation and recovery of LV function after MI.
