Responses of angiotensin-converting enzyme in the early phase of lung injury induced by acute pancreatitis in dogs
- VernacularTitle:狗急性胰腺炎早期血管紧张素转化酶的变化与肺损伤的关系
- Author:
Shaohua LI
- Publication Type:Journal Article
- Keywords:
Kininase Ⅱ;
Respiratory distress syndrome;
Pancreatitis;
Dogs
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
We observed the dynamic changes in angiotensin-converting enzyme in serum, pulmonary lymph and lung tissue after acute hemorrhagic pancreatitis induced by injection of trypsin and autobile into the pancreatic duct in dogs, Pulmonary lymph was collected for assessment of the changes in transvascular fluid and protein exchanges. The ACE activity in the mixed venous blood decreased 15 min after injection. The ACE activity in the arterial blood increased 30 rain after injection and declined 45 min later. The ACE activity in pulmonary lymph increased steadily after injection, but in the lung tissue of the pancreatitis dogs it markedly decreased comparing with that of the controls. The pulmonary lymph flow and transvascular protein clearance increased 2 to 3-fold which paralleled with the changes in ACE activity in serum and pulmonary lymph. The results indicate that the changes in ACE activity reflected the impairment of pulmonary vascular endothelial cells and could be used for the diagnosis of acute lung injury.
