The effect of vasectomy on experimental atherosclerosis
- VernacularTitle:输精管结扎对实验性动脉粥样硬化的影响
- Author:
Xuejian ZHAO
- Publication Type:Journal Article
- Keywords:
Vasectomy;
Atherosclerosis;
Lipid peroxides
- From:
Chinese Journal of Pathophysiology
1986;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Twenty vasectomized rabbits were divided into 2 groups: vasectomy stock diet (V-S) group and vasectomy cholesterol diet (V-Ch) group. In addition, 20 male rabbits of the same age were divided into correspondent control stock diet (C-S) group and control cholesterol diet (C-Ch) group. The results showed that (1) antibodies to sperm antigens were detected in 70% the vasectomized rabbits, but circulating immune complexes (CIC) was not found by two different tests in any of the vasectomized rabbits; (2) There were no lipid plaques formed in the intima of aorta and coronary artery in V-S group; (3) In rabbits of V-Ch group fed a high cholesterol diet for 12 weeks, both serum total lipid and ?-lipoprotein were significantly higher than those in C-Ch group. However, the atherosclerotic changes in aorta and coronary arteries showed no difference between the two groups both in extent and severity, implicating that vasectomy probably dose not contribute to the aggravate the process of atherosclerosis in rabbits fed a high cholesterol diet. These features might be related to the fact that there was no difference in serum lipid peroxide level between the two groups and that there was no CIC formation following vasectomy in the rabbits.
