The study of the change of glucocorticoid receptor in peripheral leukocytes from patients with chronic nephritis
- VernacularTitle:慢性肾小球肾炎病人白细胞糖皮质激素受体的变化
- Author:
Ying TIAN
- Publication Type:Journal Article
- Keywords:
Glomerulonephritis;
Receptor, steroid
- From:
Chinese Journal of Pathophysiology
1986;0(01):-
- CountryChina
- Language:Chinese
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Abstract:
This article reports, for the first time in China, the study on the change of glucocorticoid receptor (GCR) in peripheral leukocytes from 23 patients with chronic nephritis. The number of GCR was measured by the single point analysis using ~3H-Dexamethasone (~3H-Dex) as the ligand. It was found that the number of ~3H-Dex specific binding was 8825 ? 2429 sites/cell, much higher than that in normal subjects (5154 ? 1635 sites/cell, n = 22) P0.05). The concentration of plasma cortisol was determined simultaneously. It was within the normal range. There seems to be no relationship in these patients between the number of GCR and the concentration of plasma cortisol statistically (r = 0.074, n = 25). The results showed that the level of GCR in leukocytes during chronic nephritis was changed. This change had no relationship with the concentration of plasma cortison. The possible mechanism and clinic significance of the results have been discussed.
