Research progress of miRNAs regulating TLRs signaling pathway in sepsis

VernacularTitle:miRNA在脓毒症中调控TLRs信号通路的研究进展
Author: Ling XIAO ; Yu MA
Keywords: Sepsis; microRNA; Signaling pathways; TLRs
From:Chinese Journal of Emergency Medicine 2016;25(12):1340-1343
CountryChina
Language:Chinese
Abstract: Sepsis refers to the infection caused by systemic inflammatory response syndrome.Sepsis is one of the leading causes of death in critically ill patients in the ICU and its morbidity and mortality are increasing year by year globally.According to statistics,in China,the incidence of sepsis in ICU is 8.68％ and the mortality rate can be as high as 44.7％,therefore,severe sepsis in the field of medicine to become one of the problems to be overcome.MicroRNAs (miRNAs) play an important role in the pathogenesis of sepsis through the TLRs / NF-κB signaling pathways,which play an important role in immune regulation.In this review,the progress of miRNAs involved in TLRs signaling pathway in sepsis is reviewed.