Procalcitonin in guiding antibiotic use in patients with AECOPD *
10.3969/j.issn.1673-4130.2017.06.022
- VernacularTitle:降钙素原指导慢性阻塞性肺疾病急性加重期患者的抗菌药物使用
- Author:
Hongying JIANG
;
Qingjuan YANG
- Keywords:
procalcitonin;
acute exacerbation of chronic obstructive pulmonary disease;
antibiotics
- From:
International Journal of Laboratory Medicine
2017;38(6):783-785
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of procalcitonin in guiding the antibiotic use in acute exacerbation of chronic ob-structive pulmonary disease(AECOPD) .Methods A total of 184 patients with AECOPD in our hospital from March 2014 to Sep-tember 2015 were selected and divide into two groups by the random number table method .Ninety-two cases in the control group received the antibiotic therapy according to clinical experience .Ninety-two cases in the observation group was implemented the anti-biotic therapy according to serum procalcitonin level .Results Compared with before treatment ,the procalcitonin level after treat-ment in the observation group was decreased significantly (P<0 .05) .The procalcitonin level after treatment ,occurrence rate of a-cute exacerbation within six months and re-hospitalization rate within six months in the observation group were lower than those in the control group(P<0 .05) .The antibiotic use time ,antibiotic expenses ,hospitalization time and hospitalization cost in the obser-vation group were less than those in the control group(P<0 .05) .The total effective rate and hospitalization mortality rate had no statistical difference between the two groups (P>0 .05) .Conclusion Serum procalcitonin is significantly increased in the patients with AECOPD .Procalcitonin can be used for the optimized use of antibiotics .
