Observation on serum IFN-γ,IL-4 ,TGF-β1 ,IL-9 and IL-17 levels from youth patients with first episode depression
10.3969/j.issn.1673-4130.2017.06.004
- VernacularTitle:青年首发抑郁症患者血清IFN-γ、IL-4、TGF-β1、IL-9、IL-17水平检测及分析
- Author:
Jie JIANG
;
Jie ZHANG
;
Ke YIN
;
Qi XU
;
Jun HE
- Keywords:
first-episode depression;
cytokine;
amilton Depression Rating Scale;
disease course;
youth
- From:
International Journal of Laboratory Medicine
2017;38(6):729-731
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the significance of serum cytokine interferon-gamma (IFN-γ) ,interleukin-4(IL ) ,transforming growth factor-beta 1 (TGF-β1) ,interleukin-9 (IL-9) ,interleukin-17 (IL-17) in detection of youth first-episode depression .Methods Ninety cases of youth first-episode depression as the experimental group were equally divided into 3 groups according to different disease courses(<6 months ,6 months to 2 years ,>2 years)and other 30 normal persons served as the control group .The levels of serum cytokines were measured by ELISA .The level of each cytokine and Hamilton Depression Scale (HAMD) score were per-formed the Spearman correlation analysis .Results The IL-9 level in the 6 months to 2 years group and > 2 years group was high-er than that in the control group (P< 0 .05);the IFN-γlevel was negatively correlated with psychic anxiety (P<0 .05);the IL-9 level was positively correlated with the somatic anxiety and systemic symptoms (P<0 .05);the IL-17 level was positively correla-ted with the depressive mood and suicide (P<0 .05);the IFN-γlevel was positively correlated with difficulty falling asleep ,early a-wakening ,work and interest in the 6 months to 2 years group ,while positively correlated with somatic anxiety (P<0 .05);the IFN-γ level was positively correlated with depressive mood and block in the >2 years group(P<0 .05);the IL-4 level was positively correlated with the depressive mood (P<0 .05) .Conclusion Different cytokines play different roles in youth first-episode depres-sion ,cytokines may involve in the occurrence and development of depression .
