Analysis and study on serum marker level in second trimester Down′s syndrome screening in Xiangxi area*
10.3969/j.issn.1673-4130.2017.06.029
- VernacularTitle:湘西自治州妊娠中期妇女唐氏筛查血清标记物水平分析及研究
- Author:
Jia LI
;
Yalan CUI
;
Shimin HOU
;
Tong LIN
- Keywords:
Down′s syndrome;
median;
alpha-fetoprotein;
human chorionic gonadotropin
- From:
International Journal of Laboratory Medicine
2017;38(6):805-807
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the median equation of second trimester Down′s syndrome (DS) screening maternal serum markers ,alpha-fetoprotein (AFP) and human chorionic gonadotrophin (HCG) ,in Xiangxi area and to investigate the influence of new median values on the local screening results .Methods The electrochemiluminescence immunoassay (ECLIA ) was applied to detect the serum AFP and HCG levels in 2619 second-trimester normal pregnant women ,the medians of AFP and HCG in each gestational week were calculated ,and the regression equation between gestational period and the medians of AFP and HCG were es-tablished by using the statistical software ,then the results were compared with the evaluation results of software built-in medians . Results Serum AFP level was positively correlated with the gestational week (P<0 .01) ,the HCG level was negatively correlated with the gestational week (P< 0 .01);the AFP and HCG levels were negatively correlated with the body weight of pregnant woman (P<0 .01) .Before correcting the body weight ,compared with software built-in human source serum markers ,the average levels of serum AFP and HCG in Xiangxi area increased by 6 .73% and 31 .54% respectively ,the differences were statistically sig-nificant ,after correcting the software ,the screening false positive rate was remarkably decreased .Conclusion The establishment of serum maker medians for second trimester pregnant woman in Xiangxi area can increase the efficiency of the second trimester DS screening ,thus effectively screens out the DS fetus in local area .
