Research progress on the anti-tumor immunity of Th9 cells and its mechanism
10.3969/j.issn.1000-8179.2017.06.390
- VernacularTitle:Th9细胞抗肿瘤免疫作用及机制研究进展
- Author:
Kunpeng XU
;
Lujun ZHAO
- Keywords:
Th9;
IL-9;
anti-tumor immunity;
signaling pathway
- From:
Chinese Journal of Clinical Oncology
2017;44(6):294-298
- CountryChina
- Language:Chinese
-
Abstract:
As a newly identified T helper cell subset, Th9 plays an important role in anti-tumor immunity. Th9 can be differentiated from CD4+T cells that have been induced by TGF-beta and IL-4. In addition, other CD4+T helper cell subsets can be developed to Th9 cell in particular situations, thereby showing its plasticity. Results of animal experiments have indicated that Th9 inhibits tumor growth and plays a significant role in anti-tumor immunity by secreting related cytokines such as IL-9. A few cytokines and molecules can regu-late the differentiation and development of Th9 cells in different signaling pathways. This review will focus on the production, anti-tu-mor immunity, related mechanism, and signaling pathways of Th9 cells, thereby providing a new field of vision and idea for anti-tumor therapy in the future.
