Clinical study of the Chinese medicine syndrome differentiation combined with HAART for the acquried immune deficiency syndrom dementia complex
10.3760/cma.j.issn.1673-4246.2017.04.003
- VernacularTitle:中医辨证结合高效抗逆转录病毒治疗人类免疫缺陷病毒脑病临床研究
- Author:
Xue ZHANG
;
Ziqiang JIANG
;
Lihua CHEN
;
Yan SUN
;
Xuan YANG
;
Shuangli WANG
;
Yonghui AN
;
Xiaohua ZHANG
;
Min JIAO
;
Jing ZHANG
- Keywords:
HIV;
Encephalopathy;
Anti-HIV agents;
Syndrome differentiation treatment;
Clinical study
- From:
International Journal of Traditional Chinese Medicine
2017;39(4):298-302
- CountryChina
- Language:Chinese
-
Abstract:
Objecve To observe the clinical effect and safety of the Chinese medicine syndrome differentiation combined with HAART for the ADC(acquried immune deficiency syndrom dementia complex). Methods A total of 80 patients with ADC were divided into the treatment group and control group based on random number table, 40 in each group. The patients in the control group were treated by highly active anti-retrovital therapy (HAART). The patients in the treatment group were treated with TCM treatment on the based of the control group. Both groups received the treatment for 3 months.These outcomes were measured: TCM syndrome integral, mini mental state examination(MMSE), daily behavior scale(ADL), change of clinical stage, and adverse reactions. Results The effect rate of treatment group was 82.5%, which was significant higher than 65% of the control group (χ2=8.115,P=0.024). After the treatment, the ADL integral of the treatment group (37.69 ± 5.31vs.33.67 ± 5.16;t=2.528,P=0.021) was significantly higher than that before the treatment; and the ADL integral of the control group(36.96 ± 5.52vs.34.54 ± 4.98;t=2.747,P=0.027) was significantly higher than that before the treatment.But there was no significant difference between the two groups after the treatment (t=2.003,P=0.139). After the treatment, the MMSE integral of the treatment group (24.76 ± 4.43 vs.19.97 ± 5.46;t=1.006,P=0.013) was significantly higher than that before the treatment; the MMSE integral of the control group(24.65 ± 4.36 vs. 20.11 ± 4.87;t=1.035,P=0.014) was significantly higher than that before the treatment. But there was no significant difference between the two groups after the treatment (t=0.953, P=0.347).There was no significant difference between the two groups in the clinical stage change (phase1χ2=1.231,P=0.954; phase2χ2=2.726,P=1.053). There was no adverse reaction in the two groups during the treatment.Conclusions The Traditional Chinese medcine combined with HAART was better than HAART alonein the treatment of ADC.
