Measurement of prefrontal cortex and hippocampus temperature change with magnetic resonance spectroscopy for heroin addicts
10.3969/j.issn.1002-1671.2017.04.001
- VernacularTitle:海洛因依赖者前额叶皮层与海马温度改变的磁共振波谱测量
- Author:
Wenbin LIANG
;
Xinjun SUN
;
Kun ZHANG
;
Yunxia SHEN
;
Mingwu LOU
- Keywords:
brain temperature;
drug dependence;
magnetic resonance spectroscopy
- From:
Journal of Practical Radiology
2017;33(4):493-496
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate temperature changes in prefrontal cortex and hippocampus of heroin addicts with magnetic resonance spectroscopy (MRS).Methods 18 heroin addicts in the withdrawal state and 18 healthy volunteers (control group) were performed with MRS scan.First, resting-state MRS scan was performed on all subjects, and then did MRS scan again under visual stimulation while subjects were asked to carefully watch the heroin-related cue images.Measurements of NAA of the identified regions (the prefrontal cortex, bilateral hippocampus) were obtained from all subjects.Brain temperatures were calculated by the modified brain temperature-chemical shift equation.Results In resting state, the temperature of prefrontal cortex in heroin addicts group was higher than the control group, the difference was statistically significant (P<0.05),and the brain temperature was positively correlated with total dose of heroin (P<0.05).The prefrontal cortex/hippocampus temperature of heroin addicts group did not showed statistical significance between resting state and visual stimulation state (P>0.05).Conclusion MRS can be used to measure brain temperature noninvasively.Temperature change of brain may be helpful for exploring the mechanism of drug addiction and craving.
