Matrix Formulation Screening of Indomethacin Hydrophilic Gel Patch by Uniform Design
10.6039/j.issn.1001-0408.2017.10.23
- VernacularTitle:均匀设计筛选吲哚美辛亲水凝胶贴剂的基质处方
- Author:
Weijie XIE
;
Yongping ZHANG
;
Jian XU
- Keywords:
Uniform design;
Indomethacin;
Patch;
Matrix formulation;
Forming technology
- From:
China Pharmacy
2017;28(10):1382-1385
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To screen the matrix formulation of Indomethacin hydrophilic gel patch. METHODS:Using appear-ance,adhesion,softness,moisture retention as indexes,mixed level of uniform design was used to screen matrix formulation of patch,verification test and in vitro transdermal test were used to evaluate the patch quality. RESULTS:Optimized matrix formula-tion was as follow as PVA of 7.686 g,PVP of 9.662 g,glyceryl of 19.992 g,gelatin of 9.999 g,CMC-Na of 13.997 g,carbomer of 3.000 g,HPMC of 1.500 g. The prepared patch had smooth surface,uniform matrix,good color,strong adhesion,good soft-ness(water loss rate of 11.9%). It can be slowly released for 48 h. The in vitro transdermal release fitted the Higuchi model(R2=0.9869). CONCLUSIONS:Indomethacin hydrophilic gel patch is successfully prepared,which can slowly release drug with over-all good quality.
