Study on Formulation of Xiqingguo Buccal Tablet
10.6039/j.issn.1001-0408.2017.10.24
- VernacularTitle:西青果口含片的处方研究
- Author:
Yonghong XIE
;
Qing DAI
;
Hongyan ZHAO
;
Yinglan ZHAO
;
Fang LIU
;
Songqing LIU
- Keywords:
Xiqingguo;
Buccal tablet;
Formulation screening;
Orthogonal test;
Critical relative humidity
- From:
China Pharmacy
2017;28(10):1386-1388
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the formulation of Xiqingguo buccal tablet,optimize the proportion and quantity of main materials. METHODS:Using appearance,hardness,dissolution and taste as investigation indexes,orthogonal design was adopted to optimize the proportion and quantity of main thinner(lactose,mannitol),wetting agent(ethanol),lubricant(magnesium stea-rate),flavoring agent(aspartame),and critical relative humidity was detected. RESULTS:By wet granulation,the optimal formu-lation were as follows as the ratio of lactose and mannitol was 1:3,ethanol volume fraction was 60%,the dosage of menthol, magnesium stearate,aspartame and orange essence was 0.4%,0.9%,2.0%,0.4%;it was proven that the total score of 3 batches of samples were 2.67,2.67,2.70 (RSD=0.65%,n=3),respectively. The critical relative humidity of granule was 60%. CON-CLUSIONS:The Xiqingguo buccal tablet prepared by optimal prescription meets the requirements.
