Periprosthetic osteolysis induced by wear particles:research progress of calcineurin/activated T cell nuclear factor signaling pathway
10.3969/j.issn.2095-4344.2017.07.024
- VernacularTitle:假体周围磨损颗粒诱导骨溶解:钙调磷酸酶/活化T细胞核因子信号通路作用的研究进展
- Author:
Yunge ZHANG
;
Keguan SONG
- From:
Chinese Journal of Tissue Engineering Research
2017;21(7):1115-1122
- CountryChina
- Language:Chinese
-
Abstract:
BACKGROUND: Periprosthetic osteolysis and subsequent aseptic loosening are most common reasons forrevision after total joint replacements. Recently studies found that calcineurin/activated T cell nuclear factor (CN/NFAT) signaling pathway plays important roles in the pathogenic process of wear-induced inflammation and osteolysis. OBJECTIVE: To summarize CN/NFAT effects on wear particles-induced osteolysis, and to provide new ideas and newtheories for osteolysis-related diseases. METHODS: We retrieved PubMed for studies published from January 1980 to June 2016. The key words were CN/NFAT, CN/NFAT signaling pathways, wear particles, osteolysis, osteoclasts, osteoblast. Finally, 72 studies were analyzed and explored according to inclusion and exclusion criteria.RESULTS AND CONCLUSION: The pathogenesis of osteolysis involves the activation of macrophages by wear particles and the release of various proinflammatory cytokines. Bone is continuously renewed through a dynamic balance between bone resorption and formation and is the fundamental basis for maintaining normal bone mass andarchitecture by osteoclasts and osteoblasts. In this process, CN/NFAT signaling pathway is the signal transduction pathway involved in the differentiation of Ca2+ and nuclear factor kappa B receptor ligand. Osteoclasts play a significant role in both physiological and pathological bone resorption, and receptor activator of nuclear factor-κB ligand is the key cytokine that induces osteoclastogenesis.
