Liver fibrosis and stem cell therapy
10.3969/j.issn.1674-8115.2017.03.025
- VernacularTitle:肝纤维化与干细胞疗法
- Author:
Dongsheng XU
;
Aini WAN
;
Yun CHEN
;
Yang HE
;
Jianfeng YANG
;
Jian JIN
- Keywords:
liver fibrosis;
stem cell;
hepatocyte growth factor;
paracrine
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(3):403-406
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a common chronic liver disease, which is a stress response process of liver cells affected by one or more pathogenies for long term or repeatedly. During the fibrosis process, massive accumulated extracellular matrix can form scar tissue, which results in liver dysfunction or failure and seriously endangers the health of people. According to many independent reports, stem cell therapy can facilitate the alleviation of liver fibrosis. During the stem cell therapy, stem cells migrate to the injury site of liver and alleviate the liver fibrosis by improving the microenvironment of the scar area via paracrine way. This article reviews the formation, treatment, and stem cell therapy of liver fibrosis.
