Progress in the study of anti-vascular endothelial growth factor application for the treatment of neovascular age-related macular degeneration and the mechanism of poor and non-response

VernacularTitle:抗血管内皮生长因子药物治疗新生血管性老年性黄斑变性应答不良及无应答现象机制研究的进展
Author: Zifang CHENG ; Haiyan WANG ; Yusheng WANG
Keywords: Age-related macular degeneration/drug therapy; Choroidal neovascularization/drug therapy; Angiogenesis inhibitors/therapeutic use; Review
From: Chinese Journal of Ocular Fundus Diseases 2017;33(2):199-202
CountryChina
Language:Chinese
Abstract: According to the best corrected visual acuity and the morphological changes of the macular fovea,responses to the neovascular age-related macular degeneration (nAMD) who receive anti-vascular endothelial growth factor (VEGF) therapy show large variability,including poor and non-responders.Various factors will be reviewed to account for poor and non-response to anti-VEGF therapy,such as the related susceptibility genes,factors related with the development of choroidal neovascularization and morphologic parameters,pharmacokinetics and tachyphylaxis.The future research should focus on comprehensive assessment of factors affecting the efficacy of anti-VEGF therapy to improve the therapeutic outcome of nAMD.