Effect of human leukocyte antigen B*1502 genotype and age on serum homocysteine levels in children with seizures or epilepsy

VernacularTitle:人白细胞抗原B*1502基因型和年龄对抽搐或癫痫患儿血同型半胱氨酸浓度的影响
Author: Chun ZHANG ; Dake HE ; Xiaohui HUANG ; Xin WEI ; Jing MA ; Jia QI ; Yan LIU ; Ajing XU ; Shuhong BO
Keywords: homocysteine; human leukocyte antigen B*15:02; seizures; epilepsy; child
From: Journal of Clinical Pediatrics 2017;35(3):187-190
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of human leukocyte antigen B* genotype and age on serum homocysteine (Hcy) levels in children with seizures or epilepsy. Methods Fifteen children with seizures or epilepsy in whom HLA-B*15:02 genotype was detected during October 2015 to June 2016 were included. The plasma Hcy concentration in children with different genotypes was compared. The association of Hcy concentration and age was performed by linear-regression analysis. Results The mean concentration of Hcy was 8.38±4.23 μmol/L in children not carrying HLA-B*15:02 gene, which was obviously higher than that in children carrying HLA-B*15:02 gene 13.03±0.97 μmol/L (P<0.05). The Hcy concentration increased with the age (r2 =0.29, P<0.05). Conclusions Elder children with seizures or epilepsy carrying HLA-B*15:02 gene tend to have higher Hcy concentration and increased potential risk of disease. HLA-B*15:02 gene type and age can predict the changes of Hcy concentration in children with convulsions.