Metabolomics of ethyl acetate extract from Huangqi Injection on leucopenia mice
10.3969/j.issn.1001-1528.2017.03.003
- VernacularTitle:黄芪注射液乙酸乙酯萃取物对小鼠白细胞减少症作用的代谢组学
- Author:
Tingli QU
;
Erbing WANG
;
Zhenyu LI
;
Zhengbao ZHAO
;
Xuemei QIN
- Keywords:
Huangqi Injection;
ethyl acetate extract;
metabolomics;
NMR;
leucopenia
- From:
Chinese Traditional Patent Medicine
2017;39(3):455-461
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effects of ethyl acetate extract from Huangqi Injection (HQIEACE) on leucopenia mice.METHODS An experimental mouse model of leucopenia was induced by cyclophosphamide.NMR based metabolomic profiling technique coupled with multivariate statistical method was used for performing metabolomic analysis.RESULTS HQIEACE could elevate the levels of white blood cell,monocytes,neutrophils and lymphocyte in modeled mice.The levels of ten potential endogenous metabolites (lipid,leucine,3-D-hydroxybutyrate,lactate,alanine,pyruvate,creatine,scyllo-inositol,betaine and glucose) were reversed.CONCLUSION The metabolic pathways related to the pharmacological effects of HQIEACE on leucopenia are probably involved in body energy metabolism,amino acid metabolism,oxidative stress and choline metabolism.
