Shengjiang Xiexin Decoction treats irinotecan-induced delayed diarrhea in colorectal carcinoma mice
10.3969/j.issn.1001-1528.2017.03.007
- VernacularTitle:生姜泻心汤治疗伊立替康导致的结直肠癌小鼠迟发性腹泻
- Author:
Gang PENG
;
Huanyu GUAN
;
Xiaoming WANG
;
Yang HE
;
Wenting TAN
;
Yue SHI
- Keywords:
Shengjiang Xiexin Decoction;
irinotecan (CPT-11);
delayed diarrhea;
IL-15;
UGT1A1
- From:
Chinese Traditional Patent Medicine
2017;39(3):475-479
- CountryChina
- Language:Chinese
-
Abstract:
AIM To observe the therapeutic effects of Shengjiang Xiexin Decoction (Zingiberis recens Rhizoma,Zingiberis Rhizoma,Coptidis Rhizoma,etc.) on irinotecan (CPT-11)-induced delayed diarrhea in colorectal carcinoma mice and to discuss its possible action mechanism.METHODS The AOM/DSS-induced female colorectal carcinoma mice were randomly divided into normal group,model group and Shengjiang Xiexin Decoction group.The Shengjiang Xiexin Decoction group was intragastrically administered with Shengjiang Xiexin Decoction,the normal group and the model group were intragastrically administered with normal saline.The diarrhea index and rectum pathologic morphology were measured,and the β-glucuronide activity,IL-15 content and UGT1A1 expression were detected.RESULTS The diarrhea index of Shengjiang Xiexin Decoction group was significantly lower than that of the model group,which might be related to the significant inhibition of β-glucuronide activity,and sig-nificant improvement of IL-15 content and UGT1A1 expression.CONCLUSION Shengjiang Xiexin Decoction shows therapeutic effects on irinotecan-induced delayed diarrhea in AOM/DSS-induced colorectal carcinoma mice.
