Relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus
10.3969/j.issn.1674-8115.2017.03.014
- VernacularTitle:脂肪组织chemerin及其受体chemerinR基因表达与肥胖及2型糖尿病的关系
- Author:
Lingyan WANG
;
Haoyong YU
;
Li WEI
- Keywords:
chemerin gene;
chemerinR gene;
obesity;
type 2 diabetes mellitus
- From:
Journal of Shanghai Jiaotong University(Medical Science)
2017;37(3):352-358
- CountryChina
- Language:Chinese
-
Abstract:
Objective · To explore the relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus. Methods · Twenty-four patients undergoing elective abdominal surgery were enrolled, and were divided into normal glucose regulation-normal weight group (NGR-NW), normal glucose regulation-overweight/obesity group (NGR-OW/OB), and type 2 diabetic overweight/obesity group (T2DMOW/OB) according to the body mass index (BMI). The levels of chemerin and chemerinR mRNA were detected by reverse transcription PCR (RT-PCR).Results · Compare to the NGR-NW group, the chemerin mRNA levels of abdominal subcutaneous and omental fat were significantly increased in the NGR-OW/OB and T2DM-OW/OB group (P<0.05). Correlation analysis showed that the chemerin mRNA levels of abdominal omental fat were positively correlated with BMI, fasting insulin (FINS), triglyceride and serum chemerin (r=0.577, r=0.561, r=0.472, r=0.623, P<0.05 for all). The chemerin mRNA levels of abdominal subcutaneous fat showed significant positive correlation with BMI, FINS and serum chemerin (r=0.692, r=0.513, r=0.497, P<0.05 for all). Conclusion · The chemerin mRNA levels of abdominal subcutaneous and omental fat were positively correlated with BMI, FINS and serum chemerin, suggesting that the chemerin gene may play a crucial role in the pathophysiological mechanism of obesity and type 2 diabetes.
