Literature analysis on adverse drug reactions induced by Brucea Jananica Oil Injection

VernacularTitle:鸦胆子油乳注射液不良反应的文献分析
Author: Dan XIE ; Shouxiang YIN ; Peng JIANG
Keywords: Brucea Jananica Oil Injection; adverse drug reactions; literature analysis; safety of medication
From: Drug Evaluation Research 2017;40(2):266-269
CountryChina
Language:Chinese
Abstract: Objective To analyze the epidemiological characteristics of adverse drug reaction (ADR) induced by Brucea Jananica Oil Injection,through literature review and to provide theoretical support for rational use in clinic.Methods With retrospective case study,analyzed ADR induced by Brucea Jananica Oil Injection,which were searched from revelent domestic pharmaceutical database from January 1990 to September 2016.Results Totaliy 76 cases were collected,and most were middle-aged and aged patients.Males patients were more than female patients (61.84％).ADR appeared in every period.The main ADRs of Brucea Jananica Oil Injection were allergic reactions (27.71％),digestive system damage (26.51％),and skin and accessories damage (19.28％).Conclusion Brucea Jananica Oil Injection can induced various ADRs and the occurrence of ADRs was associated with a variety of factors.Clinical monitoring should be enhanced,so as to ensure safety and efficacy of medication.