Pathological evaluation of immune system in drug safety study
10.7501/j.issn.1674-6376.2017.01.001
- VernacularTitle:药物安全性研究中免疫系统的病理学评价
- Author:
Zhi LIN
;
Jianjun LV
;
Zhe QU
;
Guitao HUO
;
Di ZHENG
;
Yanwei YANG
;
Xue WANG
;
Bo LI
- Keywords:
drug safety;
immune system;
pathological evaluation;
consistency evaluation
- From:
Drug Evaluation Research
2017;40(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
The immune system is a complex system involving multiple organs,and it is vulnerable to age,gender,environment and other factors.For a variation normal physiological range,it is a great challenge to evaluate drug-induced immunotoxicity in preclinical safety study.Histomorphologic assessment of the immune system is a recognized cornerstone in the identification of immunotoxicity at present.In this paper,the principles of pathological evaluation for immune system,and pathological evaluation for important immune organs including thymus,spleen,lymph nodes are discussed briefly,so that it is intended to assist toxicity pathologists in the accurate and consistent characterization of intended and unintended drug-induced alterations of the immune system.
