Novel biomarkers for diagnosis and precision treatment of pulmonary arterial hypertension
10.7501/j.issn.1674-6376.2017.02.001
- VernacularTitle:与肺动脉高压诊断和精准治疗相关的新型生物标志物
- Author:
Xi ZHANG
;
Chao XUAN
- Keywords:
pulmonary arterial hypertension;
biomarkers;
diagnosis;
new drugs development;
precision treatment
- From:
Drug Evaluation Research
2017;40(2):141-147
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary arterial hypertension is characterized by elevated pulmonary arterial pressure with high disabled rate and lethality.Since many causes could lead to pulmonary arterial hypertension,the mechanism studies were developed rapidly,and some new therapeutic targets have been explored according to the multiple pathogenic mechanisms and pathways.We summarized the potential and novel biomarkers of the mechanisms associated with pulmonary arterial hypertension,and categorized based on their relationship to endothelial cell dysfunction,inflammation,epigenetics,cardiac function,oxidative stress,extracellular matrix,etc.The biomarkers can help for diagnosis,sorting,disease severity assessment of PAH,in order to provide the basis for precision treatment and new therapeutic target development.
