The application of different GFR estimation equations in preoperative patients with renal cell carcinoma
10.3969/j.issn.1671-8348.2017.08.019
- VernacularTitle:不同肾小球滤过率估算方程在术前肾癌患者中的临床应用研究
- Author:
Yan WU
;
Hailan SHEN
;
Yulei HOU
;
Xiaoyun BI
;
Huajian XU
;
Biao XU
;
Te CHEN
- Keywords:
kidney neoplasms;
glomerular filtration rate;
kidney function;
diagnostic performance
- From:
Chongqing Medicine
2017;46(8):1066-1069
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic performances of seven estimation formulas for glomerular filtration rate (GFR) in pre-operative patients with renal cell carcinoma.Methods A total of 386 pre-operative patients with renal cell carcinoma in the first affiliated hospital of Chongqing medical university from January 2012 to October 2014 were selected.All the patients' GFRs were measured by the renal dynamic imagingwith 99mTc-DTPA as reference (rGFR) and the seven GFR estimation equations (eGFR) were compared with the rGFR respectively.Their correlations and consistencies were observed with spearman correlation analysis and Bland and Altman analysis.The diagnostic sensitivity,specificity and likelihood ratios were calculated and the eGFR accuracies were assessed with receiver operator curve (ROC) analysis.Results The correlations between the rGFR and eGFRs were significantly (P＜0.001).In addition,CKD-EPI-Asian Crea and Ruijin formula were more accurate than others in different stages with larger ROC area in diagnosing renal cell carcinoma.Conclusion There were significant correlations between the eGFRs and rGFR,but some deviations existed.CKD-EPI-Asian Crea and Ruijin formula were more suitable for assessment of eGFR of pre-operative patients with renal cell carcinoma.However,both of these equations had a few limitations.
