Effect of trimetazidine combined with atorvastatin on cardiac function andlevel of hs-CRP, IL-6, and Fib in patients with coronary heart disease
10.7501/j.issn.1674-6376.2017.01.021
- VernacularTitle:阿托伐他汀联合曲美他嗪对冠心病患者心功能和hs-CRP、IL-6、Fib的影响
- Author:
Huan LI
;
Wen WANG
;
Yi YAN
;
Fengjun JIAO
- Keywords:
trimetazidine;
atorvastatin;
coronary heart disease;
cardiac function;
hs-CRP;
IL-6;
Fib
- From:
Drug Evaluation Research
2017;40(1):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of trimetazidine combined with atorvastatin on cardiac function and the level of hs-CRP,IL-6,and Fib in patients with coronary heart disease.Methods Patients (120 cases) with coronary heart disease in the first people's Hospital of Xianyang City from January 2014 to January 2016 were selected and randomly divided into two groups.The observation group was treated with trimetazidine combined with atorvastatin,the control group was treated with trimetazidine,the curative effect,left ventricular ejection fraction,left ventricular diastolic end systolic diameter,left ventricular posterior wall thickness and serum hs-CRP,IL-6,and Fib levels were compared.Results The effective rate of observation group was 91.67％ (55/60),significantly higher than the control group 76.67％ (46/60) (P ＜ 0.05);The left ventricular ejection fraction,left ventricular end-diastolic diameter,and left ventricular posterior wall thickness of two groups were significantly improved (P ＜ 0.05),and the improvement of the observation group was significantly better than that of control group (P ＜ 0.05);The serum levels of hs-CRP,IL-6,and Fib were significantly lower (P ＜ 0.05),and the observation group was more obvious (P ＜ 0.05);The incidence of adverse reactions of two groups had no significant difference.Conclusion Trimetazidine combined with atorvastatin have high curative effect on coronary heart disease,and can improve cardiac function,significantly reduce the levels of hs-CRP,IL-6,and Fib,worth clinical promotion.
