Glomerular C4d Deposition Is a Prognostic Factor for IgA Nephropathy
10.12007/j.issn.0258?4646.2017.01.005
- VernacularTitle:肾小球C4d沉积为IgA肾病的预后因子
- Author:
Linlin LIU
;
Nan LIU
;
Juan WANG
;
Linbo ZHU
;
Li YAO
;
Tianhua XU
;
Lining WANG
- Keywords:
complement C4d;
IgA nephropathy;
renal remission
- From:
Journal of China Medical University
2017;46(1):23-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the significance of glomerular deposition of C4d in accessing the severity and prognosis of IgA nephropathy. Methods A total of 131 patients were recruited for the study. Immunofluorescence was used to detect the deposition of C4d in renal tissue of pa?tients with IgA nephropathy,and the relationship between C4d deposition and clinical and pathological parameters and renal remission was ana?lyzed. Results Totally 30 patients had glomerular deposition of C4d. Compared with the patients without C4d deposition,the patients with C4d deposition had significantly higher levels of serum creatinine,urinary protein excretion and C4d and higher prevalence of hypertension,but had sig?nificantly decreased levels of glomerular filtration rates. With the histopathological phenotypes segregated by Lee 's classification,the ratios of C4d deposition presented an increase(P=0.005). The patients with C4d deposition had more severe mesangial proliferation,endocapillary hypercellu?larity,segmental glomerulosclerosis and tubular?interstitial injury. The rates of renal remission were significantly lower in IgA nephropathy patients with C4d deposition than those without C4d deposition(P<0.001). Conclusion IgA nephropathy patients with C4d deposition have more se?vere clinical and pathological manifestations and lower rate of renal remission. Glomerular C4d deposition is expected to be an important pathologi?cal prognostic factor for predicting the prognosis of IgA nephropathy.
